Premalignant breast neoplasia: a paradigm of interlesional and intralesional molecular heterogeneity and its biological and clinical ramifications.

Cytoplasmic Her2/neu immunohistochemical staining in breast cancer; From a molecular point of view

Evolution of tumor cell heterogeneity during progressive growth of individual lung metastases.

The metastatic properties of tumor cell clones isolated from individual lesions of B16 melanoma metastatic to lung have been examined at different stages in the evolution of metastasis. Clonal analysis of metastatic lesions produced by B16 melanoma populations containing clones with identifiable, stable drug-resistance markers revealed that the majority (greater than 80%) of experimental metast...

Cutaneous pseudolymphoma of the breast

Cutaneous pseudolymphoma (PL) refers to a reactive T or B- cell proliferative disorder in reaction to some known or unknown stimuli. The most common site of involvement of pseudolymphoma is the face followed by the scalp. Because of its similarity with true lymphoma in both clinical and pathological aspects, differentiating between them is often difficult but fundamental due to their completely...

Molecular Identification of Human Papiloma Virus (HPV) in Cervical Neoplasia and the Risk Factors Affecting Cervical Cancer in Isfahan

The rate of cervical cancer in Asians is deferent, based on the risk factors affecting and the rate of papiloma virus infection among females. Cervical cancer is one of the important cancers between Iranian women. In the present study the rate of cervical neoplasia was detected in Isfahan and some risk factors affecting the incidence of cervical cancer was analyzed. The human papiloma virus inf...

Tackling intra- and inter-tumor heterogeneity to combat triple negative breast cancer.

Rampant inter-patient and intra-tumor heterogeneity present formidable challenges in the clinical management of triple-negative breast cancer (TNBC) and mandate a "divide-and-conquer" approach wherein deep biomarker profiling drives patient segmentation and development of customized treatments. Genomic and proteomic studies have uncovered several TNBC subtypes each of which represents a distinc...